Biosynthesis of Astrocytic Trehalose Regulates Neuronal Arborization in Hippocampal Neurons.

@article{Martano2017BiosynthesisOA,
  title={Biosynthesis of Astrocytic Trehalose Regulates Neuronal Arborization in Hippocampal Neurons.},
  author={Giuseppe Martano and Laura Gerosa and Ilaria Prada and Giulia Garrone and Vittorio Krogh and Claudia Verderio and Maria Passafaro},
  journal={ACS chemical neuroscience},
  year={2017},
  volume={8 9},
  pages={
          1865-1872
        }
}
Trehalose is a nonreducing disaccharide that has recently attracted much attention because of its ability to inhibit protein aggregation, induce autophagy, and protect against dissections and strokes. In vertebrates, the biosynthesis of trehalose was long considered absent due to the lack of annotated genes involved in this process. In contrast, trehalase (TreH), which is an enzyme required for the cleavage of trehalose, is known to be conserved and expressed. Here, we show that trehalose is… CONTINUE READING
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