Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils

  title={Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils},
  author={{\AA}sa Brunnstr{\"o}m and Mats Hamberg and William J. Griffiths and Bengt Mannervik and H E Cla{\'e}sson},
Hepoxilins are epoxy alcohols synthesized through the 12-lipoxygenase (12-LO) pathway in animal cells. The epidermis is the principal source of hepoxilins in humans. Here we report on the formation of novel hepoxilin regioisomers formed by the 15-LO pathway in human cells. The Hodgkin lymphoma cell line L1236 possesses high 15-lipoxygenase-1 (15-LO-1) activity and incubation of L1236 cells with arachidonic acid led to the formation of 11(S)-hydroxy-14(S),15(S)-epoxy 5(Z),8(Z),12(E… 
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The Rat Leukocyte-type 12-Lipoxygenase Exhibits an Intrinsic Hepoxilin A3 Synthase Activity*
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Stereoselective biosynthesis of hepoxilin B3 in human epidermis.
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