Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola.

@article{Wight2009BiosynthesisAR,
  title={Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola.},
  author={Wanessa D Wight and K Kim and Christopher B. Lawrence and Jonathan D. Walton},
  journal={Molecular plant-microbe interactions : MPMI},
  year={2009},
  volume={22 10},
  pages={1258-67}
}
Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC). A chemically unrelated HDAC inhibitor, HC toxin, was earlier shown to be a major virulence factor in the interaction between Cochliobolus carbonum and its host, maize. In order to test whether depudecin is also a virulence factor for A. brassicicola, we identified the genes for depudecin biosynthesis and created depudecin-minus mutants. The… CONTINUE READING

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