Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus

  title={Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus},
  author={Jianhua Zhu and Mingxuan Wang and Wei Wen and Rong-min Yu},
  booktitle={Pharmacognosy reviews},
Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has been investigated for many years, for scientific interest and for their potential in manufacturing applications, to fulfill the market demand. In this review, the progress and perspective of C. roseus… CONTINUE READING

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Effects of low light on terpenoid indole alkaloid accumulation and related biosynthetic pathway gene expression in leaves of Catharanthus roseus seedlings

Y Liu, D Zhao, +3 authors Y Jiang
Bot Stud 2011;52:191-6 • 2011

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