Biosynthesis and homeostatic roles of nitric oxide in the normal kidney.

  title={Biosynthesis and homeostatic roles of nitric oxide in the normal kidney.},
  author={Bruce C. Kone and Christine Baylis},
  journal={The American journal of physiology},
  volume={272 5 Pt 2},
Nitric oxide (NO) is an important molecular mediator of numerous physiological processes in virtually every organ. In the kidney, NO plays prominent roles in the homeostatic regulation of glomerular, vascular, and tubular function. Differential expression and regulation of the NO synthase (NOS) gene family contribute to this diversity of action. This review explores recent advances in the molecular and cell biology of the NOS isoforms and relates these findings to functions of NO in the control… CONTINUE READING

From This Paper

Topics from this paper.
158 Citations
195 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 158 extracted citations


Publications referenced by this paper.
Showing 1-10 of 195 references

Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae

  • P. W. Shaul, E. J. Smart, I. S. Yuhanna, R. G. Anderson
  • J . BioZ . Chem .
  • 1996

Bradyki - nin stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton

  • V. J. Venema, M. B. Marrero
  • J . BioZ . Chem .
  • 1996

Burns . Nitric oxide stimulates guanylate cyclase and regulates sodium transport in rabbit proximal tubule

  • A Roczniak, D. K.
  • Am . J . Physiol . 270 ( Renal FZuid EZectroZyte…
  • 1996

Similar Papers

Loading similar papers…