Biosynthesis and function of beta 1,6 branched mucin-type glycans.

  title={Biosynthesis and function of beta 1,6 branched mucin-type glycans.},
  author={Paul V. Beum and P. W. Cheng},
  journal={Advances in experimental medicine and biology},
The contribution of carbohydrate structure to biomolecular, cellular, and organismal function is well-established, but has not yet received the attention it deserves, perhaps due to the complexity of the structures involved and to a lack of simple experimental methods for relating structure and function. In particular, beta1,6 GlcNAc branching plays a key functional role in processes ranging from inflammation and immune system function to tumor cell metastasis. For instance, synthesis of the… CONTINUE READING

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