Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.

@article{Liu1996BiosynthesisAF,
  title={Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.},
  author={Wei Liu and Per Hellman and Qi Li and Wen Ru Yu and Claes Juhlin and Hans Nordlinder and Ola Rollman and G{\"o}ran {\AA}kerstr{\"o}m and Hans T{\"o}rm{\"a} and H{\aa}kan Melhus},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={229 3},
  pages={922-9}
}
We demonstrate that cultured human and bovine parathyroid cells incubated with all-trans-[11,12-3H]-retinol convert this tracer into all-trans- and 9-cis-retinoic acid. By using RT-PCR, cellular retinol-binding protein type I (CRBP I), cellular retinoic acid binding protein I and II (CRABP I and II), retinoic acid receptors (RARs) alpha, beta and gamma, and 9-cis-retinoic acid receptor (RXR) alpha transcripts were detected in human parathyroid cDNA. CRBP I and CRABP I expression was confirmed… CONTINUE READING