Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae.

Abstract

Pikromycin-related macrolides have recently attracted significant research interest because they are structurally related to the semisynthetic ketolide antibiotics that have demonstrated promising potential in combating multi-drug-resistant respiratory pathogens. Cloning and in-depth studies of the pikromycin biosynthetic gene cluster from Streptomyces… (More)

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@article{Xue2001BiosynthesisAC, title={Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae.}, author={Y. Xue and D. H. Sherman}, journal={Metabolic engineering}, year={2001}, volume={3 1}, pages={15-26} }