Biosynthesis and charging of pyrrolysine, the 22nd genetically encoded amino acid.

  title={Biosynthesis and charging of pyrrolysine, the 22nd genetically encoded amino acid.},
  author={C. Hertweck},
  journal={Angewandte Chemie},
  volume={50 41},
  • C. Hertweck
  • Published 27 July 2011
  • Biology, Chemistry
  • Angewandte Chemie
Considering the vast number of diverse proteins and enzymes that support all kinds of cellular functions, it is amazing that a basic set of only 20 canonical amino acid residues is sufficient to meet all needs. This holds true for virtually all cases, yet a few enzymes require the 21st proteinogenic amino acid, the cysteine homologue selenocysteine. Only recently, there has been another remarkable addition to the family of genetically encoded amino acids: pyrrolysine (Pyl, 1). Krzycki and… 

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