Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs

@article{Manzoni2002BiosynthesisAB,
  title={Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs},
  author={Matilde Manzoni and Manuela Rollini},
  journal={Applied Microbiology and Biotechnology},
  year={2002},
  volume={58},
  pages={555-564}
}
  • M. Manzoni, M. Rollini
  • Published 14 February 2002
  • Biology, Chemistry
  • Applied Microbiology and Biotechnology
Abstract. Hypercholesterolemia is considered an important risk factor in coronary artery disease. Thus the possibility of controlling de novo synthesis of endogenous cholesterol, which is nearly two-thirds of total body cholesterol, represents an effective way of lowering plasma cholesterol levels. Statins, fungal secondary metabolites, selectively inhibit hydroxymethyl glutaryl-coenzyme A (HMG-CoA) reductase, the first enzyme in cholesterol biosynthesis. The mechanism involved in controlling… 
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