Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs

@article{Manzoni2002BiosynthesisAB,
  title={Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs},
  author={Matilde Manzoni and Manuela Rollini},
  journal={Applied Microbiology and Biotechnology},
  year={2002},
  volume={58},
  pages={555-564}
}
Abstract. Hypercholesterolemia is considered an important risk factor in coronary artery disease. Thus the possibility of controlling de novo synthesis of endogenous cholesterol, which is nearly two-thirds of total body cholesterol, represents an effective way of lowering plasma cholesterol levels. Statins, fungal secondary metabolites, selectively inhibit hydroxymethyl glutaryl-coenzyme A (HMG-CoA) reductase, the first enzyme in cholesterol biosynthesis. The mechanism involved in controlling… Expand
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