Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.

@article{Robel1995BiosynthesisAA,
  title={Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.},
  author={Paul Robel and Jennifer E. Young and C. Corpechot and Willy Mayo and F Perch{\'e} and Marc Haug and Herv{\'e} Simon and Etienne Emile Baulieu},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1995},
  volume={53 1-6},
  pages={355-60}
}
Pregnenolone (PREG), synthesized de novo in rodent brain, is the precursor of PREG sulfate (S) and progesterone (PROG). PROG is further converted to 5 alpha-pregnane 3, 20-dione (DH PROG) and to 3 alpha-hydroxy-5 alpha-pregnan-20-one (TH PROG). PROG, DH PROG and TH PROG have been measured in the brain of male and female rats. Neither PROG nor DH PROG disappeared from brain, contrary to plasma, after combined adrenalectomy (ADX) and gonadectomy (CX). Trilostane decreased PROG and increased PREG… CONTINUE READING