Biosynthesis and apical localization of the urokinase receptor in polarized MDCK epithelial cells.

@article{Limongi1995BiosynthesisAA,
  title={Biosynthesis and apical localization of the urokinase receptor in polarized MDCK epithelial cells.},
  author={P Limongi and Massimo Resnati and L Hernandez-Marrero and Ottavio Cremona and Francesco Blasi and Francesca Fazioli},
  journal={FEBS letters},
  year={1995},
  volume={369 2-3},
  pages={207-11}
}
The biosynthesis and the surface localization of the urokinase plasminogen activator receptor (uPAR) were analysed in MDCK epithelial cells and in unpolarized fibroblasts. No differences were observed with respect to rate of synthesis, nature of precursors and time of surface appearance. uPAR was localized particularly at the focal and cell-cell contacts when expressed in fibroblasts. On the contrary, in MDCK cells uPAR was found mostly on the apical surface; in agreement with its localization… CONTINUE READING