Biosynthesis and Reactivity of Cysteine Persulfides in Signaling.

  title={Biosynthesis and Reactivity of Cysteine Persulfides in Signaling.},
  author={Pramod Kumar Yadav and Michael Martinov and Victor M. Vitvitsky and Javier G. Seravalli and Rudolf Wedmann and Milos R Filipovic and Ruma Banerjee},
  journal={Journal of the American Chemical Society},
  volume={138 1},
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thiols to persulfides. However, the source of the persulfide donor and whether its relationship to H2S is as a product or precursor is controversial. The transsulfuration pathway enzymes can synthesize cysteine persulfide (Cys-SSH) from cystine and H2S… CONTINUE READING