Biosynthesis, transport, and modification of lipid A.

  title={Biosynthesis, transport, and modification of lipid A.},
  author={M. Stephen Trent},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={82 1},
  • M. Stephen Trent
  • Published 2004 in
    Biochemistry and cell biology = Biochimie et…
Lipopolysaccharide (LPS) is the major surface molecule of Gram-negative bacteria and consists of three distinct structural domains: O-antigen, core, and lipid A. The lipid A (endotoxin) domain of LPS is a unique, glucosamine-based phospholipid that serves as the hydrophobic anchor of LPS and is the bioactive component of the molecule that is associated with Gram-negative septic shock. The structural genes encoding the enzymes required for the biosynthesis of Escherchia coli lipid A have been… CONTINUE READING

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