Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells.

@article{Yang2002BiosynthesisIT,
  title={Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells.},
  author={Wenbo Yang and Michael S. Kilberg},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 41},
  pages={
          38350-7
        }
}
  • Wenbo Yang, Michael S. Kilberg
  • Published in
    The Journal of biological…
    2002
  • Biology, Medicine
  • Rat C6 glioma cells were used as a model system to study the biosynthesis, intracellular targeting, and degradation of the EAAC1 transporter, a sodium-dependent glutamate/aspartate transport protein that encodes System X(-)A,G activity. At steady state, nearly 70% of the EAAC1 transporter was located at the cell surface. The newly synthesized EAAC1 protein was co-translationally N-glycosylated with high mannose oligosaccharide chains that were processed into complex-type sugar chains as the… CONTINUE READING

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