Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives

@article{Jung2009BiosynthesisBP,
  title={Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives},
  author={Hyung-Moo Jung and M. Jeya and Sang-Yong Kim and Hee-Jung Moon and Raushan Kumar Singh and Ye-Wang Zhang and Jung-Kul Lee},
  journal={Applied Microbiology and Biotechnology},
  year={2009},
  volume={84},
  pages={417-428}
}
The glycopeptide teicoplanin isolated from the fermentation broth of Actinoplanes teichomyceticus is used to treat serious Gram-positive bacterial infections that are resistant to other antibiotics, e.g. β-lactams. The long time frame and progressively broader clinical use of teicoplanin has eventually led to the emergence and spreading of resistance in enterococci and staphylococci towards the antibiotics. Given the structural complexity of the natural product, only fermentative routes are… 

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