Biosynthesis, Maturation, Release, and Degradation of Neurotensin and Neuromedin N

@article{Kitabgi1992BiosynthesisMR,
  title={Biosynthesis, Maturation, Release, and Degradation of Neurotensin and Neuromedin N},
  author={P. Kitabgi and F. Nadai and C. Rov{\`e}re and J. Bidard},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={668}
}
The cloning in 1987 of the neurotensin (NT) precursor' has revealed that it contains several possible dibasic maturation sites, and therefore has the capability to generate a number of different peptides, two of them being the biologically active peptides NT, the focus of this volume, and neuromedin N (NN), a NT-related peptide that was isolated in 1984 from porcine spinal cord' (see also the two preceding chapters of this volume). In order to understand the physiology of the NT/NN producing… Expand
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67 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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67 Citations

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Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases
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BON cells display the intestinal pattern of neurotensin/neuromedin N precursor processing
  • 28
Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines
  • P. Kitabgi
  • Chemistry, Medicine
  • Journal of Molecular Medicine
  • 2006
  • 20
Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat—I. Biochemical characterization of maturation products
  • 18
Inactivation of neurotensin and neuromedin N by Zn metallopeptidases
  • 23
A common precursor to neurotensin and LANT6 and its differential processing in chicken tissues
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Enhanced expression of neurotensin/neuromedin N mRNA and products of NT/NMN precursor processing in neonatal rats
  • 11
Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat—II. Immunohistochemical localization of maturation products
  • 22
PC12 cells can be induced to produce, but do not process, the neurotensin/neuromedin N precursor
  • 17
Chapter VI Neurotensin receptors in the central nervous system
  • 11
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References

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Calcium-dependent release of neuromedin N and neurotensin from mouse hypothalamus
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Differential processing of the neurotensin/neuromedin N precursor in the mouse
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Differential processing of neurotensin/neuromedin N precursor(s) in canine brain and intestine.
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Neuromedin-N is not released with neurotensin from rat ileum.
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Catabolism of neurotensin by neural (neuroblastoma clone N1E115) and extraneural (HT29) cell lines
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Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.
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Marked variations of the relative distributions of neurotensin and neuromedin N in micropunched rat brain areas suggest differential processing of their common precursor
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Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases.
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The characterization and regional distribution of neuromedin N-like immunoreactivity in rat brain using a highly sensitive and specific radioimmunoassay. Comparison with the distribution of neurotensin
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High‐Affinity Receptor Sites and Rapid Proteolytic Inactivation of Neurotensin in Primary Cultured Neurons
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