Biostructural chemistry of magnesium. regulation of mithramycin-DNA interactions by Mg2+ coordination.

@article{Huang1995BiostructuralCO,
  title={Biostructural chemistry of magnesium. regulation of mithramycin-DNA interactions by Mg2+ coordination.},
  author={H. W. Huang and D. Li and J. Cowan},
  journal={Biochimie},
  year={1995},
  volume={77 9},
  pages={
          729-38
        }
}
  • H. W. Huang, D. Li, J. Cowan
  • Published 1995
  • Chemistry, Medicine
  • Biochimie
  • Divalent magnesium promotes the selective binding of mithramycin to a cognate DNA sequence (5'-XXGCXX-3') by a coupled mechanism requiring local conformational changes in the polynucleotide backbone and a structural rearrangement of the mithramycin dimer. Circular dichroism, 31P-NMR, and analysis of the topological change of supercoiled plasmid DNA by agarose gel electrophoresis support these conclusions and offer insight on the regulatory role of Mg2+. Molecular modeling suggests that sequence… CONTINUE READING
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