Bioreducible polymers for gene silencing and delivery.

  title={Bioreducible polymers for gene silencing and delivery.},
  author={Sejin Son and Ran Namgung and Jihoon Kim and K. Anand Kumar Singha and Won Jong Kim},
  journal={Accounts of chemical research},
  volume={45 7},
Polymeric gene delivery vectors show great potential for the construction of the ideal gene delivery system. These systems harness their ability to incorporate versatile functional traits to overcome most impediments encountered in gene delivery: from the initial complexation to their target-specific release of the therapeutic nucleic acids at the cytosol. Among the numerous multifunctional polymers that have been designed and evaluated as gene delivery vectors, polymers with redox-sensitive… CONTINUE READING