Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery.

  title={Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery.},
  author={Qi Yin and Yu Gao and Zhiwen Zhang and Pengcheng Zhang and Yaping Li},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={151 1},
RNA interference (RNAi) mediating gene silencing is a promising approach in the area of gene therapy, but it still is a major challenge to find new non-viral vectors with high transfection efficiency and low toxicity until today. In this work, three novel bioreducible poly (β-amine esters) (PAEs) with different amino monomers in the main chain were designed and synthesized by Michael addition polymerization. All PAEs could condense shRNA into complex nanoparticles with particle size (60-200nm… CONTINUE READING
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