Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview.

  title={Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview.},
  author={Felix Garcia-Ochoa and Emilio G{\'o}mez},
  journal={Biotechnology advances},
  volume={27 2},
In aerobic bioprocesses, oxygen is a key substrate; due to its low solubility in broths (aqueous solutions), a continuous supply is needed. The oxygen transfer rate (OTR) must be known, and if possible predicted to achieve an optimum design operation and scale-up of bioreactors. Many studies have been conducted to enhance the efficiency of oxygen transfer. The dissolved oxygen concentration in a suspension of aerobic microorganisms depends on the rate of oxygen transfer from the gas phase to… CONTINUE READING
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