Bioreactor for a larger scale hepatocyte in vitro perfusion.

  title={Bioreactor for a larger scale hepatocyte in vitro perfusion.},
  author={Joerg C. Gerlach and Jens Encke and Oliver Hole and Christian M{\"u}ller and Carolyn J. Ryan and Peter Neuhaus},
  volume={58 9},
A bioreactor construction for hepatocytes and liver sinusoidal endothelial cells is described. The reactor is based on capillaries for hepatocyte immobilization. Four discrete capillary membrane systems, each serving different purposes, are woven to create a three-dimensional framework for decentralized cell perfusion with low metabolite gradients and decentralized oxygenation and CO2 removal. The biochemical performance of reactors initially seeded with 2.5 x 10(9) hepatocytes were evaluated… CONTINUE READING


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