Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.

@article{Yu2004BioreactorbasedBT,
  title={Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.},
  author={Xiaojun Yu and Edward A. Botchwey and Elliot M. Levine and Solomon R. Pollack and Cato Laurencin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 31},
  pages={11203-8}
}
An important issue in tissue engineering concerns the possibility of limited tissue ingrowth in tissue-engineered constructs because of insufficient nutrient transport. We report a dynamic flow culture system using high-aspect-ratio vessel rotating bioreactors and 3D scaffolds for culturing rat calvarial osteoblast cells. 3D scaffolds were designed by mixing lighter-than-water (density, <1g/ml) and heavier-than-water (density, >1g/ml) microspheres of 85:15 poly(lactide-co-glycolide). We… CONTINUE READING
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