Biopsy or debulking surgery as initial surgery for locally advanced rhabdomyosarcomas in children?

@article{Cecchetto2007BiopsyOD,
  title={Biopsy or debulking surgery as initial surgery for locally advanced rhabdomyosarcomas in children?},
  author={Giovanni Cecchetto and Gianni Bisogno and Federica De Corti and Patrizia Dall'Igna and Alessandro Inserra and Andrea Ferrari and Alberto Garaventa and Angela Scagnellato and Modesto Carli},
  journal={Cancer},
  year={2007},
  volume={110}
}
The purpose of the current study was to analyze the influence of the initial surgical approach (biopsy vs resection with macroscopic residual tumors) on the outcome of patients with localized Intergroup Rhabdomyosarcoma Study (IRS) Group III rhabdomyosarcoma (RMS) enrolled in the Italian studies between 1979 and 2003. 
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References

SHOWING 1-10 OF 22 REFERENCES
Results of treatment of fifty‐six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: A report from The Intergroup Rhabdomyosarcoma Study‐IV, 1991–1997
We reviewed 56 IRS‐IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum/pelvis to assess outcome and prognostic factors, including the value of initially excising ≥50% of the
Surgical Principles for Children/Adolescents With Newly Diagnosed Rhabdomyosarcoma: A Report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
TLDR
The current surgical therapy recommen-dations of the Soft Tissue Sarcoma Committee of the Children’s Oncology Group (COG), formerly known as the Intergroup Rhabdomyosarcoma Group (IRSG), are described.
Does debulking improve survival rate in advanced-stage retroperitoneal embryonal rhabdomyosarcoma?
Topical topic: value of fine needle aspiration biopsy in childhood rhabdomyosarcoma: twenty-six years of experience in Slovenia.
TLDR
FNAB is a safe method, which enables us to establish the pre-treatment diagnosis of RMS, and to some extent even its type, without delay, and FNAB successfully replaced surgical biopsy in 87% of R MS patients during the last 15 years.
Childhood rhabdomyosarcoma.
A malignant tumor of striated muscle origin, Rhabdomyosarcoma (RMS) is a childhood tumor that has benefited from nearly 30 years of multimodality therapy culminating in a greater than 70% overall
Results of treatment for soft tissue sarcoma in childhood and adolescence: a final report of the German Cooperative Soft Tissue Sarcoma Study CWS-86.
TLDR
The improved design of the study incorporating risk-adapted radiotherapy allowed treatment to be reduced for selected groups of patients without compromising survival.
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
TLDR
VAC and VAI or VIE with surgery (with or without RT), are equally effective for patients with local or regional rhabdomyosarcoma and are more effective for embryonal tumors than therapies used previously.
Thoracic sarcomas in children.
TLDR
Overall survival was significantly associated with clinical group, size, and local or distant recurrence, but not with histology or IRS study by univariate analysis, and outcome was better for patients with totally resected or microscopically residual tumor after resection.
Surgical risk factors in primary surgery for localized neuroblastoma: the LNESG1 study of the European International Society of Pediatric Oncology Neuroblastoma Group.
TLDR
The adoption of SRFs as predictors of adverse surgical outcome was validated because their presence was associated with lower complete resection rate and greater risk of surgery-related complications.
...
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