Biopsy or debulking surgery as initial surgery for locally advanced rhabdomyosarcomas in children?

  title={Biopsy or debulking surgery as initial surgery for locally advanced rhabdomyosarcomas in children?},
  author={Giovanni Cecchetto and Gianni Bisogno and Federica De Corti and Patrizia Dall'Igna and Alessandro Inserra and Andrea Ferrari and Alberto Garaventa and Angela Scagnellato and Modesto Carli},
The purpose of the current study was to analyze the influence of the initial surgical approach (biopsy vs resection with macroscopic residual tumors) on the outcome of patients with localized Intergroup Rhabdomyosarcoma Study (IRS) Group III rhabdomyosarcoma (RMS) enrolled in the Italian studies between 1979 and 2003. 
Margin Analysis: Sarcoma of the Head and Neck.
Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: A report from the cooperative soft tissue sarcoma trial CWS‐96
To analyze the clinical course, treatment modalities, complications and outcome of patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma (BPRMS) treated on the CWS‐96 trial.
Management of Rhabdomyosarcoma in Pediatric Patients.
In most patients, except those with small resectable low-grade lesions, adjuvant radiotherapy and chemotherapy is added to maximize local control with variable results.
Consensus and controversies regarding the treatment of rhabdomyosarcoma
This work assembled a panel of pediatric and adolescent and young adult sarcoma experts to develop treatment guidelines for managing RMS and created algorithms incorporating evidence‐based care for patients with RMS, emphasizing the importance of clinical trials and close integration of all specialties.
Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group.
GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma
All patients with RMS should receive chemotherapy, either at diagnosis in advanced or metastatic stages, or after initial resection in early local stages, depending on site, stage, histology and response to chemotherapy.
Aggressive Embryonal Orbital Rhabdomyosarcoma in an Adolescent
A case of a 12- year-old girl with embryonal orbital rhabdomyosarcoma which is a rare occurrence among adolescents and its management challenges is presented.
Challenges in the Local Treatment of Large Abdominal Embryonal Rhabdomyosarcoma
Children with LARME have a fair prognosis, despite an often huge tumor size and unfavorable primary site, if the tumors can either be resected or irradiated following induction chemotherapy.


Results of treatment of fifty‐six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: A report from The Intergroup Rhabdomyosarcoma Study‐IV, 1991–1997
We reviewed 56 IRS‐IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum/pelvis to assess outcome and prognostic factors, including the value of initially excising ≥50% of the
Surgical Principles for Children/Adolescents With Newly Diagnosed Rhabdomyosarcoma: A Report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
The current surgical therapy recommen-dations of the Soft Tissue Sarcoma Committee of the Children’s Oncology Group (COG), formerly known as the Intergroup Rhabdomyosarcoma Group (IRSG), are described.
Does debulking improve survival rate in advanced-stage retroperitoneal embryonal rhabdomyosarcoma?
Topical topic: value of fine needle aspiration biopsy in childhood rhabdomyosarcoma: twenty-six years of experience in Slovenia.
FNAB is a safe method, which enables us to establish the pre-treatment diagnosis of RMS, and to some extent even its type, without delay, and FNAB successfully replaced surgical biopsy in 87% of R MS patients during the last 15 years.
Childhood rhabdomyosarcoma.
A malignant tumor of striated muscle origin, Rhabdomyosarcoma (RMS) is a childhood tumor that has benefited from nearly 30 years of multimodality therapy culminating in a greater than 70% overall
Results of treatment for soft tissue sarcoma in childhood and adolescence: a final report of the German Cooperative Soft Tissue Sarcoma Study CWS-86.
The improved design of the study incorporating risk-adapted radiotherapy allowed treatment to be reduced for selected groups of patients without compromising survival.
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
VAC and VAI or VIE with surgery (with or without RT), are equally effective for patients with local or regional rhabdomyosarcoma and are more effective for embryonal tumors than therapies used previously.
Thoracic sarcomas in children.
Overall survival was significantly associated with clinical group, size, and local or distant recurrence, but not with histology or IRS study by univariate analysis, and outcome was better for patients with totally resected or microscopically residual tumor after resection.
Surgical risk factors in primary surgery for localized neuroblastoma: the LNESG1 study of the European International Society of Pediatric Oncology Neuroblastoma Group.
The adoption of SRFs as predictors of adverse surgical outcome was validated because their presence was associated with lower complete resection rate and greater risk of surgery-related complications.