Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study.

Abstract

BACKGROUND/AIMS To assess the incidence of gastric cancer development in gastric benign ulcer patients and to evaluate the value of biopsy by taking specimens from both the base and edges of ulcers in contrast to the traditional biopsy which takes specimens from the edges of ulcers only. METHODOLOGY An endoscopic followup of more than 1 year was conducted on 456 gastric ulcer patients in our hospital for a duration over 8 years. We collected clinical, endoscopic and pathological data and obtained at least 6 biopsies from both the edges and the bases of ulcers healing or complete healing, respectively and assessed H. pylori infection. RESULTS Gastric cancers developed in 11 (2.41%) of 456 GU patients. In the experimental group, 3 cases that were diagnosed by histology showed adenocarcinoma with specimens taken from the ulcer bases and in the other 5 cases the specimens were taken from the ulcer edges. The detection rate of gastric cancer from gastric ulcer between experimental group and control group was statistically significant (4.57% vs. 1.07%, p<0.05). CONCLUSIONS Gastric ulcer may develop into gastric cancer over a certain period of time in patients infected with H. pylori. Biopsies from ulcer bases and edges at the second or subsequent endoscopies may lead to defection of gastric cancer earlier and more effectively than the biopsies which take specimens from the edges of ulcers only.

DOI: 10.5754/hge10692

Cite this paper

@article{Lv2012BiopsyFT, title={Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study.}, author={Sheng-Xiang Lv and Jian-he Gan and Xing-Gang Ma and Chang-Cheng Wang and Hong-mei Chen and Erping Luo and Xiao-ping Huang and Shao-hong Wu and Ai-Lan Qin and Ke-Chen and Xiao-Hong Wang and Wei-Sun and Li-Chen and Ying-Xie and Feng-xia Hu and Dan-Niu and Sarika Walia and Jian Zhu}, journal={Hepato-gastroenterology}, year={2012}, volume={59 115}, pages={947-50} }