Bioprospecting for antagonistic Penicillium strains as a resource of new antitumor compounds

  title={Bioprospecting for antagonistic Penicillium strains as a resource of new antitumor compounds},
  author={R. Nicoletti and E. Buommino and A. Filippis and M. P. L{\'o}pez-Gresa and E. Manzo and A. Carella and M. Petrazzuolo and M. Tufano},
  journal={World Journal of Microbiology and Biotechnology},
  • R. Nicoletti, E. Buommino, +5 authors M. Tufano
  • Published 2008
  • Biology
  • World Journal of Microbiology and Biotechnology
  • Microorganisms are increasingly exploited as a source of new pharmaceuticals. Soil fungi are particularly promising to this regard since their biocenotic competitiveness is often based on the production of antibiotics and other inhibitory substances. About 15 Penicillium strains possessing some extent of antifungal ability were evaluated as a possible source of antitumor products based on the antiproliferative and pro-apoptotic effects of their culture extracts on human tumor cell lines. About… CONTINUE READING
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