Bioprocess equipment: characterization of energy dissipation rate and its potential to damage cells.

@article{Mollet2004BioprocessEC,
  title={Bioprocess equipment: characterization of energy dissipation rate and its potential to damage cells.},
  author={Mike Mollet and Ningning Ma and Yang Zhao and Robert Brodkey and Ron Taticek and Jeffrey J Chalmers},
  journal={Biotechnology progress},
  year={2004},
  volume={20 5},
  pages={1437-48}
}
A study was conducted in which analytical, computational, and experimental measurements combined with analysis were made to characterize the local energy dissipation rate in a variety of conditions, vessels, and geometries that animal cells would encounter in typical bioprocessing situations. With no gas-liquid interfaces present, as expected, the local energy dissipation rate is typically orders of magnitude lower than what has been experimentally demonstrated to catastrophically damage… CONTINUE READING