Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

  title={Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips},
  author={Kimberly A. Homan and David B. Kolesky and Mark A. Skylar-Scott and Jessica Herrmann and Humphrey Obuobi and Annie Moisan and Jennifer A Lewis},
  booktitle={Scientific reports},
Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within an extracellular matrix and housed in perfusable tissue chips, allowing them to be maintained for greater than two months. Their convoluted tubular architecture is circumscribed by proximal tubule epithelial… CONTINUE READING
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