Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

@inproceedings{Homan2016BioprintingO3,
  title={Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips},
  author={Kimberly A. Homan and David B. Kolesky and Mark A. Skylar-Scott and Jessica Herrmann and Humphrey Obuobi and Annie Moisan and Jennifer A Lewis},
  booktitle={Scientific reports},
  year={2016}
}
Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within an extracellular matrix and housed in perfusable tissue chips, allowing them to be maintained for greater than two months. Their convoluted tubular architecture is circumscribed by proximal tubule epithelial… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

A quantitative approach to screen for kidney toxic compounds in vitro

  • M Adler
  • J. Am. Soc. Nephrol
  • 2015

Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane

  • Schophuizen, M C.
  • Acta Biomater
  • 2015

living membranes that actively transport organic cations

  • Jansen, J. et al. Human proximal tubule epithelial cells cult fibers
  • Scientific reports 5, 16702, doi: 10.1038…
  • 2015

Similar Papers

Loading similar papers…