Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems.

  title={Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems.},
  author={Lorenz Uebersax and Hans Peter Merkle and Lorenz Meinel},
  journal={Tissue engineering. Part B, Reviews},
  volume={15 3},
The extracellular matrix of tissues is regarded as a physiological depot for various growth factors (GFs), from where they are to be released into the surrounding tissue and play their natural roles in tissue regulation. In addition to autocrine and paracrine cell signaling, they provide specific extracellular information necessary to conduct tissue homeostasis and (re)generation. This review will detail on various physiological concepts that have evolved during evolution to control the… CONTINUE READING


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