Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.

  title={Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.},
  author={Vladimir N. Uversky and David Eliezer},
  journal={Current protein & peptide science},
  volume={10 5},
Parkinson's disease (PD) is a slowly progressive movement disorder that results from the loss of dopaminergic neurons in the substantia nigra, a small area of cells in the mid-brain. PD is a multifactorial disorder with unknown etiology, in which both genetic and environmental factors play important roles. Substantial evidence links alpha-synuclein, a small highly conserved presynaptic protein with unknown function, to both familial and sporadic PD. Rare familial cases of PD are associated with… CONTINUE READING
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