Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.

@article{Pugsley2015BiophysicsAM,
  title={Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.},
  author={Michael K. Pugsley and Michael J. Curtis and Eric S Hayes},
  journal={Handbook of experimental pharmacology},
  year={2015},
  volume={229},
  pages={149-203}
}
Cardiac safety pharmacology is a continuously evolving discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment of a new chemical entity (NCE). The aim of cardiac safety pharmacology is to characterise the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects on the heart using continuously evolving methodology. Unlike Toxicology, safety pharmacology includes within its remit a… CONTINUE READING