Biophysical studies on agents affecting the state of membrane lipids: Biochemical and pharmacological implications

@article{Lenaz2004BiophysicalSO,
  title={Biophysical studies on agents affecting the state of membrane lipids: Biochemical and pharmacological implications},
  author={Giorgio Lenaz and Giovanna Curatola and Laura Mazzanti and Giovanna Parenti-Castelli},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={22},
  pages={3-32}
}
SummaryThe phospholipid requirement of membrane-bound enzymes may depend on several reasons. In our laboratory we have investigated lipids (1) as a bidimensional medium required for the movement of Coenzyme Q, a lipid-soluble cofactor of the mitochondrial respiratory chain, and (2) as a hydrophobic environment necessary to impose the proper conformation to membrane-bound enzymic proteins.We have found that Coenzyme Q, once reduced by NADH dehydrogenase, must cross the inner mitochondrial… 

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