Biophysical studies of matrix metalloproteinase/triple-helix complexes.

  title={Biophysical studies of matrix metalloproteinase/triple-helix complexes.},
  author={Gregg B Fields},
  journal={Advances in protein chemistry and structural biology},
Several members of the zinc-dependent matrix metalloproteinase (MMP) family catalyze collagen degradation. The structures of MMPs, in solution and solid state and in the presence and absence of triple-helical collagen models, have been assessed by NMR spectroscopy, small-angle X-ray scattering, and X-ray crystallography. Structures observed in solution exhibit flexibility between the MMP catalytic (CAT) and hemopexin-like (HPX) domains, while solid-state structures are relatively compact… CONTINUE READING