Biophysical properties of Ca2+- and Mg-ATP-activated K+ channels in pulmonary arterial smooth muscle cells isolated from the rat

@article{Albarwani1994BiophysicalPO,
  title={Biophysical properties of Ca2+- and Mg-ATP-activated K+ channels in pulmonary arterial smooth muscle cells isolated from the rat},
  author={Sulayma Albarwani and Blair E. Robertson and Piers C. G. Nye and Roland Z. Kozlowski},
  journal={Pfl{\"u}gers Archiv},
  year={1994},
  volume={428},
  pages={446-454}
}
A novel class of Ca2+-activated K+ channel, also activated by Mg-ATP, exists in the main pulmonary artery of the rat. In view of the sensitivity of these “KCa,ATP” channels to such charged intermediates it is possible that they may be involved in regulating cellular responses to hypoxia. However, their electrophysiological profile is at present unknown. We have therefore characterised the sensitivity of KCa,ATP channels to voltage, intracellular Ca2+ ([Ca2+]i) and Mg-ATP. They have a… CONTINUE READING

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