Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression.

@article{Earnshaw2006BiophysicalMO,
  title={Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression.},
  author={Berton A. Earnshaw and Paul C. Bressloff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 47},
  pages={12362-73}
}
AMPA receptors mediate the majority of fast excitatory synaptic transmission in the CNS, and evidence suggests that AMPA receptor trafficking regulates synaptic strength, a phenomenon implicated in learning and memory. There are two major mechanisms of AMPA receptor trafficking: exocytic/endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion or hopping of surface receptors between the postsynaptic density and the surrounding extrasynaptic membrane… CONTINUE READING

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