Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis.

@article{Yablonskiy2012BiophysicalMO,
  title={Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis.},
  author={Dmitriy A. Yablonskiy and Jie Luo and Alexander L. Sukstanskii and Aditi Iyer and Anne H. Cross},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 35},
  pages={14212-7}
}
Phase images obtained with gradient echo MRI provide image contrast distinct from T1- and T2-weighted images. It is commonly assumed that the local contribution to MRI signal phase directly relates to local bulk tissue magnetic susceptibility. Here, we use Maxwell's equations and Monte Carlo simulations to provide theoretical background to the hypothesis that the local contribution to MRI signal phase does not depend on tissue bulk magnetic susceptibility but tissue magnetic architecture… CONTINUE READING
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