Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles.

@article{BeckBroichsitter2014BiophysicalIO,
  title={Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles.},
  author={Moritz Beck-Broichsitter and Clemens Ruppert and Thomas Schmehl and Andreas G{\"u}nther and Werner Seeger},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 1 Pt B},
  pages={474-81}
}
Reasonable suspicion has accumulated that inhaled nano-scale particulate matter influences the biophysical function of the pulmonary surfactant system. Hence, it is evident to provide novel insights into the extent and mechanisms of nanoparticle-surfactant interactions in order to facilitate the fabrication of safe nanomedicines suitable for pulmonary applications. Negatively- and positively-charged poly(styrene) nanoparticles (diameters of ~100nm) served as model carriers. Nanoparticles were… CONTINUE READING

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