Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

@article{Hansen2006BiophysicalCO,
  title={Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].},
  author={Rie Schultz Hansen and Thomas Goldin Diness and Torsten Christ and Erich Wettwer and Ursula Ravens and S Olesen and Morten Grunnet},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 4},
  pages={
          1319-29
        }
}
Within the field of new antiarrhythmic compounds, the interesting idea of activating human ether-a-go-go-related gene (HERG1) potassium channels has recently been introduced. Potentially, drugs that increase HERG1 channel activity will augment the repolarizing current of the cardiac myocytes and stabilize the diastolic interval. This may make the myocardium more resistant to events that cause arrhythmias. We here present the compound N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3… CONTINUE READING

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Mechanism of action of a novel human ether-a-go-go-related gene channel activator

O Casis, SP Olesen, MC Sanguinetti
  • Mol Pharmacol
  • 2006
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