Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain.


FAAP20 (Fanconi anemia-associated protein 20) is a subunit of the Fanconi anemia (FA) core complex that repairs interstrand cross-links. To understand the molecular basis for the FA core complex-mediated recruitment of Rev1 to the DNA lesion, we characterized the interactions among FAAP20-UBZ4, Rev1-BRCT, and ubiquitin using NMR. We found that FAAP20-UBZ4… (More)
DOI: 10.1016/j.febslet.2015.08.021

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