• Corpus ID: 11590051

Biophysical characterization of the honeybee DSC 1 orthologue reveals a novel voltage-dependent Ca 2 + channel subfamily : CaV 4 Pascal

  title={Biophysical characterization of the honeybee DSC 1 orthologue reveals a novel voltage-dependent Ca 2 + channel subfamily : CaV 4 Pascal},
  author={Gosselin ‐ Badaroudine and Moreau and Simard and Cens and Rousset and Collet and Charnet and Chahine},
Voltage-gated Na and Ca channels (NaV and CaV) belong to the large family of ion channels and feature four homologous domains, each containing six transmembrane (TM) segments. NaV channels initiate the action potentials of many excitable cells, thus regulating their electrical signals. CaV channels have been attributed more diverse roles, which is expected, because they would have emerged earlier in evolution and are permeable to Ca, a major second messenger. They are involved in pacemaker cell… 


Role of the DSC1 Channel in Regulating Neuronal Excitability in Drosophila melanogaster: Extending Nervous System Stability under Stress
Electrophysiological analysis of the giant fiber system (GFS), a well-defined central neural circuit, revealed that DSC1 mutants are altered in the activities of the GFS, including the ability of theGFS to follow repetitive stimulation and response to heat shock, starvation, and pyrethroid insecticides.
Evolution of sodium channels predates the origin of nervous systems in animals
A phylogeny infer ancestral states of the ion selectivity filter and show that this state has been retained in the choanoflagellate and placozoan channels and identifies key gene duplications and losses and shows convergent amino acid replacements at important points along the animal lineage.
Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila.
The deduced amino acid sequence of a Drosophila gene isolated with a vertebrate sodium channel complementary DNA probe revealed an organization virtually identical to the vertebrate sodium channel
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
It is reported that the beta-subunit binds to the cytoplasmic linker between repeats I and II of the dihydropyridine-sensitive alpha 1-subunits from skeletal and cardiac muscles, and also with the more distantly related neuronal alpha 1A and omega-conotoxin GVIA-sensitivealpha 1B-sub units.
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes.
With both heart and brain RNA at least two distinct types of calcium ion conductance were found, distinguishable by their time course and inactivation properties, and in oocytes injected with heart RNA the slowly inactivating component was selectively blocked by the calcium-channel antagonist nifedipine.
Calcium-dependent inactivation of neuronal calcium channels
A structural understanding of this mechanism will provide a framework for understanding the regulation of Ca2+ entry and accumulation in neurons.
Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides
The functional expression and the molecular, biophysical, and pharmacological characterization of the western honeybee’s sodium channel are reported and could be used to assess the risks that current and next generation pesticides pose to honeybee populations.