Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.

@article{Gell2002BiophysicalCO,
  title={Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.},
  author={David A. Gell and Yi Kong and Sally A. Eaton and Mitchell J Weiss and Joel P. Mackay},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 43},
  pages={40602-9}
}
Alpha-hemoglobin stabilizing protein (AHSP) is a small (12 kDa) and abundant erythroid-specific protein that binds specifically to free alpha-(hemo)globin and prevents its precipitation. When present in excess over beta-globin, its normal binding partner, alpha-globin can have severe cytotoxic effects that contribute to important human diseases such as beta-thalassemia. Because AHSP might act as a chaperone to prevent the harmful aggregation of alpha-globin during normal erythroid cell… CONTINUE READING

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