Biophysical characterization of cationic lipid: DNA complexes.

  title={Biophysical characterization of cationic lipid: DNA complexes.},
  author={Simon J Eastman and Craig S. Siegel and Jennifer D Tousignant and Adam E Smith and Seng H. Cheng and Ronald K. Scheule},
  journal={Biochimica et biophysica acta},
  volume={1325 1},
To better understand the structures formed by the interaction of cationic lipids with DNA, we undertook a systematic analysis to determine the biophysical characteristics of cationic lipid:DNA complexes. Four model cationic lipids with different net cationic charge were found to interact in similar ways with DNA when that interaction was compared in terms of the apparent molar charge ratio of lipid to DNA. When DNA was present in charge excess over the cationic lipid, the complex carried a net… CONTINUE READING

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