Biophysical characterisation of the recombinant human frataxin precursor

Abstract

Friedreich's ataxia is a disease caused by a decrease in the levels of expression or loss of functionality of the mitochondrial protein frataxin (FXN). The development of an active and stable recombinant variant of FXN is important for protein replacement therapy. Although valuable data about the mature form FXN81-210 has been collected, not enough… (More)
DOI: 10.1002/2211-5463.12376

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