Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis

@article{Chatelier2010BiophysicalCO,
  title={Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis},
  author={Aurelien Chatelier and Juan Zhao and Patrick Bois and Mohamed Chahine},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2010},
  volume={460},
  pages={77-86}
}
Nav1.6 is the major voltage-gated sodium channel at nodes of Ranvier. This channel has been shown to produce a robust persistent inward current in whole-cell experiments. Nav1.6 plays an important role in axonal conduction and may significantly contribute to the pathophysiology of the injured nervous system through this persistent current. However, the underlying molecular mechanisms and regulation of the persistent current are not well understood. Using the whole-cell configuration of the… CONTINUE READING

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