Biophysical assessment of DC iontophoresis and current density on transdermal permeation of methotrexate

Abstract

INTRODUCTION The effect of DC iontophoresis using low (0.2 mA/cm(2)) and high current density (0.5 mA/cm(2)) on transdermal permeation of methotrexate loaded into polyacrylamide hydrogel patch was investigated. RESULTS Flux of 20.57 ± 1.02 μg/cm(2)/h and 36.8 ± 2.21 μg/cm(2)/h was achieved with low and high current density DC iontophoresis, respectively… (More)
DOI: 10.4103/2230-973X.93011

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