Biophysical aspects of microsphere engulfment by human neutrophils.

  title={Biophysical aspects of microsphere engulfment by human neutrophils.},
  author={Scott I Simon and Geert W Schmid-Sch{\"o}nbein},
  journal={Biophysical journal},
  volume={53 2},
A quantitative investigation into the mechanism of neutrophil phagocytosis of opsonized microspheres possessing well defined dimensions was undertaken. Three aspects were documented: membrane conservation, cell adhesion to the spheres, and active cell cytoplasmic projection around the microspheres. The physical act of internalizing a particle by a cell involves a reduction in its plasma membrane area and an increase in its volume. As a consequence, a cell can internalize only a finite number of… CONTINUE READING