Biophysical aspects of P-glycoprotein-mediated multidrug resistance.

  title={Biophysical aspects of P-glycoprotein-mediated multidrug resistance.},
  author={Randy M Wadkins and Paul D Roepe},
  journal={International review of cytology},
In the 45 years since Burchenal's observation of chemotherapeutic drug resistance in tumor cells, many investigators have studied the molecular basis of tumor drug resistance and the phenomenon of tumor multidrug resistance (tumor MDR). Examples of MDR in microorganisms have also become topics of intensive study (e.g., Plasmodium falciparum MDR and various… CONTINUE READING