Biophysical and immunological characterization of 2-dRib modified HSA and its implications in diabetes mellitus.

@article{Saifi2018BiophysicalAI,
  title={Biophysical and immunological characterization of 2-dRib modified HSA and its implications in diabetes mellitus.},
  author={Ishrat Jahan Saifi and K M Neelofar and Masihur Rehman Ajmal and Sheelu Shafiq Siddiqi},
  journal={International journal of biological macromolecules},
  year={2018},
  volume={113},
  pages={
          294-299
        }
}
Glycoxidation of protein may lead to develop diabetes. In the present study, different concentrations of 2-deoxy d-ribose (2-dRib) were used to modify human serum albumin (HSA). Nitro Blue Tetrazolium (NBT) assay results showed that yield of the fructosamine content was directly proportional to the concentration of 2-dRib. UV and fluorescence spectroscopy results showed an increment in hyperchromicity and decrease in fluorescence intensity of 2-dRib modified HSA as compared to native HSA… CONTINUE READING
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