Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.

  title={Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.},
  author={Virna Dapi{\'c} and Vedra Abdomerovi{\'c} and Rachel Marrington and Jemma C Peberdy and Alison Rodger and John O. Trent and Paula J. Bates},
  journal={Nucleic acids research},
  volume={31 8},
Single-stranded guanosine-rich oligodeoxyribonucleotides (GROs) have a propensity to form quadruplex structures that are stabilized by G-quartets. In addition to intense speculation about the role of G-quartet formation in vivo, there is considerable interest in the therapeutic potential of quadruplex oligonucleotides as aptamers or non-antisense antiproliferative agents. We previously have described several GROs that inhibit proliferation and induce apoptosis in cancer cell lines. The activity… CONTINUE READING


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