Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutes

@inproceedings{Sharma2013BiophysicalFO,
  title={Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutes},
  author={Sunil V. Sharma and Miriam Arbach and Alexandra A. Roberts and Colin J. Macdonald and Murree Groom and Chris J. Hamilton},
  booktitle={Chembiochem : a European journal of chemical biology},
  year={2013}
}
Bacillithiol (BSH) is the major low-molecular-weight (LMW) thiol in many low-G+C Gram-positive bacteria (Firmicutes). Evidence now emerging suggests that BSH functions as an important LMW thiol in redox regulation and xenobiotic detoxification, analogous to what is already known for glutathione and mycothiol in other microorganisms. The biophysical properties and cellular concentrations of such LMW thiols are important determinants of their biochemical efficiency both as biochemical… CONTINUE READING

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